Categorie
Ramiprilum [Latin]
Les marques,
Ramiprilum [Latin]
Analogs
Ramiprilum [Latin]
Les marques melange
No information avaliable
Ramiprilum [Latin]
Formule chimique
C23H32N2O5
Ramiprilum [Latin]
RX lien
http://www.rxlist.com/cgi/generic/ramipril.htm
Ramiprilum [Latin]
FDA fiche
Ramiprilum [Latin]
msds (fiche de securite des materiaux)
Ramiprilum [Latin]
Synthese de reference
EH Gold et coll., US. 4.587.258 (1967).
Ramiprilum [Latin]
Poids moleculaire
416.511 g/mol
Ramiprilum [Latin]
Point de fusion
109 oC
Ramiprilum [Latin]
H2O Solubilite
3.5mg / L
Ramiprilum [Latin]
Etat
Solid
Ramiprilum [Latin]
LogP
3.149
Ramiprilum [Latin]
Formes pharmaceutiques
Capsule
Ramiprilum [Latin]
Indication
Pour les diurétiques et les digitaliques dans l'insuffisance cardiaque congestive tant que thérapie adjuvante et pour une utilisation en prophylaxie de post-IM.
Ramiprilum [Latin]
Pharmacologie
Le ramipril est un inhibiteur de l'enzyme de conversion (IEC) similaire à bénazépril, le fosinopril, le quinapril et l'. Une prodrogue inactive, le ramipril est converti en ramiprilate dans le foie et est utilisé pour traiter l'échec d'hypertension et de cœur, afin de réduire la protéinurie et la maladie rénale chez les patients avec néphropathie, et de prévenir les AVC, infarctus du myocarde et décès d'origine cardiaque à haut risque des patients.
Ramiprilum [Latin]
Absorption
Le degré d'absorption d'au moins 50-60% et n'est pas significativement influencée par la présence d'aliments dans le tractus gastro-intestinal, même si le taux d'absorption est réduite.
Ramiprilum [Latin]
Toxicite
Les manifestations cliniques les plus probables seraient les symptômes attribuables à une hypotension. DL50 = 10933 mg / kg (par voie orale chez la souris).
Ramiprilum [Latin]
Information pour les patients
Pregnancy: Female patients of childbearing age should be told about the consequences of second- and
third-trimester exposure to ACE inhibitors, and they should also be told that these consequences do not appear to
have resulted from intrauterine ACE-inhibitor exposure that has been limited to the first trimester. These patients
should be asked to report pregnancies to their physicians as soon as possible.
Angioedema: Angioedema, including laryngeal edema, can occur with treatment with ACE inhibitors,
especially following the first dose. Patients should be so advised and told to report immediately any signs or
symptoms suggesting angioedema (swelling of face, eyes, lips, or tongue, or difficulty in breathing) and to take no
more drug until they have consulted with the prescribing physician.
Symptomatic Hypotension: Patients should be cautioned that lightheadedness can occur, especially
during the first days of therapy, and it should be reported. Patients should be told that if syncope occurs, ramipril
should be discontinued until the physician has been consulted.
All patients should be cautioned that inadequate fluid intake or excessive perspiration, diarrhea, or vomiting can
lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope.
Hyperkalemia: Patients should be told not to use salt substitutes containing potassium without
consulting their physician.
Neutropenia: Patients should be told to promptly report any indication of infection (e.g.,
sore throat, fever), which could be a sign of neutropenia.
Ramiprilum [Latin]
Organismes affectes
Les humains et autres mammifères